Government announces Taxpayer funding to create the most advanced genomic healthcare system in the world, helping to save lives and improve health outcomes
Patients with cancer and children born with treatable rare genetic diseases are set to benefit from earlier diagnosis and faster access to treatment, following a £175 million boost to cutting-edge genomics research announced by the Health and Social Care Secretary today.
The Taxpayer funding will enable research which could deliver world-leading genomic healthcare to patients, which involves the study of people’s DNA. The boost is part of a new three-year plan to develop, evaluate and roll out new technologies across the health and care system and life sciences sector, bolstering the UK’s position as a life sciences superpower. This includes:
The government has also today announced up to £25 million of UKRI-MRC funding for a UK-wide new initiative on functional genomics, an area of genomic research which uses molecular tools such as gene editing to improve understanding of how genetic variation leads to disease and support smarter diagnostics and the discovery of new treatments. The Life Sciences Vision set out in 2021 commits to delivering a world-class offer on functional genomics and the UK is in a strong position to become a leader in this area.
These announcements will build on the world-leading work of the NHS Genomic Medicine Service.
Health and Social Care Secretary Steve Barclay said:
Thousands of children are born in the UK every year with a treatable rare condition that could be detected using genome sequencing. Most rare disorders are genetic and children under the age of five are disproportionately affected. Whilst these conditions are often difficult to identify, genomic testing has already become the main way of providing a diagnosis.
The current NHS heel prick blood test carried out as part of newborn screening is used to detect nine rare but serious health conditions in babies, including sickle cell disease and cystic fibrosis. However, screening a baby’s entire genome – all of their DNA – alongside the current heel prick could detect hundreds more rare, treatable diseases in their first years of life. For many of these illnesses early and effective intervention is crucial for helping these children live healthier lives.
The Newborn Genomes Programme will support vital healthcare research to enable better diagnostics and treatments to be developed and explore the potential benefits of safely and securely storing a patient’s genome on record to help predict, diagnose and treat future illnesses through their lifetime. For example, if a child who has had their genome sequenced falls sick when they are older, such as developing cancer, there may be an opportunity to use their stored genetic information to help diagnose and treat them.
A public consultation by Genomics England has shown overall support for the use of genomics in newborn screening, providing the right safeguards are in place. Genomics England engaged widely with the public, parents, families with rare disease, and healthcare professionals and scientists to navigate the scientific, clinical, ethical, and societal issues that newborn genome sequencing presents.
Minister for Health, Will Quince, said:
Alongside this, as part of their innovative cancer programme, Genomics England will partner with NHSE England (NHSE) to test new genomic sequencing technology for faster, more accurate cancer diagnosis. Working with NHSE and the National Pathology Imaging Co-operative (NPIC), Genomics England will also combine imaging, genomic, and clinical data to better diagnose and predict the progress of a patient’s cancer.
To overcome the lack of diversity within genomic data, Genomics England will expand a range of programmes to build trusting relationships with traditionally excluded groups of people, such as patients with sickle cell disease who are unrepresented in research studies, alongside developing tools to enable doctors and researchers to better interpret genetic variations and make more informed decisions about patient care. This will help tackle health inequalities and improve patient outcomes within genomic medicine.
Business Secretary Grant Shapps said:
NHS England National Medical Director Professor Sir Stephen Powis said:
As set out in the government’s genomic healthcare strategy, Genome UK, the ambition is to create the most advanced genomic healthcare system in the world. This will be underpinned by the latest scientific advances and engagement with patients and the public, developing the genomics workforce and supporting industrial growth. This will deliver better health outcomes at lower cost alongside commitments to enable more rapid diagnosis.
This comes as the government announced £113 million of funding last month for innovative research into cutting-edge new treatments including cancer immune therapies or vaccines and game-changing weight loss medication and technologies, to accelerate their development and rollout as part of the Life Sciences Vision.
Professor Lucy Chappell, Chief Scientific Advisor to DHSC and CEO of the NIHR, said:
Dr Rich Scott, Chief Medical Officer for Genomics England, said:
Professor John Iredale, Executive Chair of the Medical Research Council, said:
ABPI’s director of research policy, Dr Jennifer Harris said:
Steve Bates OBE, CEO of the BioIndustry Association, said:
Background Information